Buy VP10 Peptide 10mg | VIP (10-28) Fragment
⚠️ Research Notice
All products listed on this e-commerce storefront are available exclusively for in vitro laboratory experimentation, chemical analysis, and scientific research usage.
Technical Specifications
- Product Name: VP10 Peptide
- Alternative Name: Vasoactive Intestinal Peptide (10-28) Fragment
- CAS Registry Number: 69856-17-3
- Amino Acid Sequence: Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
- Molecular Formula: C105H180N32O26S
- Molecular Weight: 2338.87 g/mol
- Purity Level: Greater than or equal to 99% (HPLC/MS Lab Verified)
- Physical Format: Sterile, white freeze-dried powder vial
Purchasing Options & Bulk Pricing
We supply premium, synthetic VP10 peptide 10mg vials built specifically for high-purity chemical testing. As a dedicated research chemical vendor, we keep reliable stock ready to go, handle logistics quickly, and maintain strict quality control guidelines.
Unverified suppliers can easily ruin your study datasets. To protect your materials, we store every single batch in climate-controlled environments right up until dispatch. This extra care ensures your lab gets completely uncompromised chemicals.
| Order Quantity | Price Per 10mg Vial | Expected Delivery Timeline |
|---|---|---|
| 1 – 4 Vials | $79.00 USD | 2 to 3 Business Days |
| 5 – 9 Vials | $71.00 USD | 2 to 3 Business Days |
| 10 – 24 Vials | $63.00 USD | Free Express Shipping (1-2 Days) |
| 25+ Vials (Wholesale) | Contact Account Representative | Tailored Freight Manifest |
Running a large-scale clinical screen? Get in touch with our support office for custom wholesale pricing tiers.
Quality Assurance & Packaging
Rigorous HPLC and mass spectrometry testing verifies every single batch of our 10mg research vials. We ship a physical Certificate of Analysis (CoA) with your order to prove your batch hits the mandatory 99% purity mark. This transparency gives you reproducible data across your assays.
We pack our compounds into vacuum-sealed amber glass vials. Light and moisture quickly degrade these peptides if left exposed. Our packaging protocol stops this damage completely, keeping the structural integrity intact during transit.
Research Mechanisms
Receptor Binding Profile
In vitro models show that the VIP (10-28) fragment works as a highly effective competitive antagonist at VIP receptor sites. During tests using HT29 colonic adenocarcinoma cultures, the VP10 fragment binds to target receptors securely without triggering cyclic AMP (cAMP) synthesis. This distinct binding profile makes it an ideal control compound when you need to isolate VPAC1 and VPAC2 receptor responses.
| Receptor Target | Mechanism Type | Direct Experimental Outcome |
|---|---|---|
| VPAC1 Receptor | Competitive Antagonist | Blocks cyclic AMP (cAMP) synthesis activation |
| VPAC2 Receptor | High Affinity Antagonist | Inhibits downstream intracellular signaling cascades |
| Macrophage Profiles | Neuroimmune Modulator | Triggers measurable upregulation of biological markers |
Target Mapping
Researchers use this 19-amino acid sequence to map out the exact binding domains of native Vasoactive Intestinal Peptide. The fragment lacks the internal activation sequence, which lets it block endogenous VIP from triggering cellular cascades. This blockade gives your team clean, clear data on G-protein coupled receptor pathways.
Key Laboratory Application Studies
Vasodilation Studies
Data reveals that the VIP 10-28 sequence plays a massive role in tracking skin blood flow changes during hyperthermic stress. Microdialysis experiments show that introducing this specific peptide fragment dampens the usual spike in localized blood flow from heat exposure. Labs buy this compound to break down the pathways linking nitric oxide synthase and histamine reactions.
Multiple comparative studies highlight how this compound changes systemic heat dispersal models. Local blood vessels show a much weaker dilation response when you apply the antagonist. This reaction confirms that native VIP handles the heavy lifting for vasodilation, making the VP10 fragment an essential tool for cardiovascular research.
Neuroimmune Signaling
Native VIP regulates the immune system by turning down specific pro-inflammatory cytokines like TNF-alpha and IL-6. Using the VP10 fragment in your active research models lets you block these pathways entirely. This isolation helps map out how neuroendocrine systems talk to automated inflammatory responses.
Laboratories worldwide use this compound to study the thin line between neurogenic inflammation and autoimmune balance. If you introduce the antagonist into a macrophage environment, you can easily track the rapid spike in inflammatory markers. The experiment clearly shows the protective qualities that native neuropeptides naturally provide.
Chemical Architecture
Getting accurate results with automated assays requires a solid understanding of the VIP (10-28) fragment’s structural layout. Our product features a strictly synthesized sequence of nineteen specific amino acid chains. The structure mirrors the exact binding affinity of native human, porcine, and rat VIP, giving you translatable data for multi-species academic research.
The molecular weight sits right at 2338.87 g/mol. Our lab team optimizes the structure during synthesis to cut down on common peptide fragmentation issues. Because we enforce these tight quality benchmarks, our inventory is a reliable choice for demanding biochemical testing.
FAQ
Shipping Logistics: How do you handle shipping for 10mg peptide vials?
We ship our 10mg vials as highly stable, lyophilized powder. The freeze-dried format allows the peptide to survive normal room temperatures during shipping without breaking down or losing potency. Because of this stability, standard shipments do not need cold packs.
Billing Protocols: What payment methods do you take?
Our secure checkout takes major credit cards, bank wire transfers, and verified corporate purchase orders. We encrypt all your purchase data to safeguard your billing and institutional privacy. If you run into any issues at checkout, our team can manually generate an invoice for your lab.
Laboratory Handling: How should I store this when it arrives?
Keep unopened lyophilized vials in the freezer at -20°C for long-term storage. Once you reconstitute the peptide for testing, keep the liquid solution in the fridge at 4°C and use it within 14 days to prevent degradation. We highly recommend mapping out your fluid math before mixing.
Bulk Orders: Do you offer bulk discounts for major screening projects?
Yes, we offer tiered discounts for universities, biotech firms, and contract research organizations (CROs). Reach out through our wholesale portal with your estimated monthly vial volume. A commercial account representative will put together a custom quote and shipping manifest for you.
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